Treatment of Osteoporosis - FORTEO (teriparatide [rDNA origin] injection)

WHAT´S NEXT AFTER
OSTEOPOROTIC FRACTURE?

CONSIDER FORTEO TO HELP REDUCE THE RISK OF FRACTURE AND HELP FORM NEW BONE

Find out who may need anabolic action for new bone

MANY PATIENTS DO NOT RECEIVE OSTEOPOROSIS TREATMENT AFTER AN OSTEOPOROTIC FRACTURE^†1

Clinical signs and symptoms of vertebral fracture may include²:

Height loss
Kyphosis
Acute back pain

Consider FORTEO for patients with³:

Multiple risk factors for fracture
(eg, family history, age, low BMD)⁴
One or more osteoporotic fractures
For patients who fail on or are intolerant to
other osteoporosis therapy

Is it time to help form new bone?

HELP FORM NEW BONE
WITH FORTEO

MicroCT images are of paired iliac crest bone biopsies at baseline and after 21 months of treatment with FORTEO. These biopsies are from a 65-year-old postmenopausal woman with osteoporosis with a baseline T-score of –2.7 at the total hip who had a BMD response that was representative of the treatment group.^5,6

Bone biopsies were obtained from a subset of women (n=51) who participated in the Fracture Prevention Trial, a multicenter, prospective, double-blind trial of FORTEO 20 mcg/day (n=541) vs placebo (n=544). 1,637 postmenopausal women with osteoporosis, of whom 90% had a prevalent vertebral fracture at baseline, were evaluated. Mean age: 69. Median duration of exposure to therapy: 19 months (maximum 24 months). All received 1,000 mg/day of calcium and 400–1,200 IU/day of vitamin D.^3,5,7

When is the right time for new bone?

*Offer is subject to eligibility; please see rules and restrictions or call 1-800-LillyRx.
†Data from a large, retrospective study of 21,192 patients enrolled in the Pennsylvania Pharmaceutical Assistance Contract for the Elderly (PACE). PACE allows eligible lower-income Medicare beneficiaries to purchase medications for a small co-payment. Patients were included in the study if they had been enrolled in PACE and Medicare for 2 consecutive years from 1994 to 2000, and had a hip or wrist fracture. Prescription data were examined to determine whether patients received a medication for osteoporosis before or after a fracture. In the year 2000, there were 2,436 hip fractures and 1,620 wrist fractures. Of these fracture patients (total N=4,056), only 898 (22%) filled a prescription for an osteoporosis medication in the 6 months after the fracture. There was no difference in the likelihood of starting medication by fracture type (wrist vs hip).

References: 1. Solomon DH, et al. Am J Med. 2003;115:398-400. 2. International Osteoporosis Foundation. The Breaking Spine. Revised 2010. Available at: http://www.iofbonehealth.org/sites/default/files/PDFs/WOD%20Reports/2010_the_breaking_spine_en.pdf. Accessed November 8, 2012. 3. FORTEO Prescribing Information. 4. National Osteoporosis Foundation. Clinician's Guide to Prevention and Treatment of Osteoporosis. Revised January 2010. Available at: http://www.nof.org/files/nof/public/content/file/344/upload/159.pdf. Accessed November 8, 2012. 5. Jiang Y, et al. J Bone Miner Res. 2003;18:1932-1941. 6. Data on file, Lilly Research Laboratories (FOR20100215A). 7. Neer RM, et al. N Engl J Med. 2001;344:1434-1441.

INDICATIONS AND USAGE

FORTEO is indicated for the treatment of postmenopausal women with osteoporosis at high risk for fracture, to increase bone mass in men with primary or hypogonadal osteoporosis at high risk for fracture, and for the treatment of men and women with osteoporosis associated with sustained, systemic glucocorticoid therapy (daily dosage equivalent to 5 mg or greater of prednisone) at high risk for fracture
High risk for fracture is defined as a history of osteoporotic fracture, multiple risk factors for fracture, or patients who have failed or are intolerant to other available osteoporosis therapy

FORTEO is administered as a
20-microgram once-daily dose and is available in a 2.4-mL prefilled delivery device for subcutaneous injection over 28 days.

IMPORTANT SAFETY INFORMATION

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Forteo

WHAT´S NEXT AFTEROSTEOPOROTIC FRACTURE?

CONSIDER FORTEO TO HELP REDUCE THE RISK OF FRACTURE AND HELP FORM NEW BONE

MANY PATIENTS DO NOT RECEIVE OSTEOPOROSIS TREATMENT AFTER AN OSTEOPOROTIC FRACTURE†1

Clinical signs and symptoms of vertebral fracture may include2:

Consider FORTEO for patients with3:

HELP FORM NEW BONE WITH FORTEO

INDICATIONS AND USAGE

IMPORTANT SAFETY INFORMATION

Forteo

For Healthcare Professionals

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WHAT´S NEXT AFTER
OSTEOPOROTIC FRACTURE?

MANY PATIENTS DO NOT RECEIVE OSTEOPOROSIS TREATMENT AFTER AN OSTEOPOROTIC FRACTURE^†1

Clinical signs and symptoms of vertebral fracture may include²:

Consider FORTEO for patients with³:

HELP FORM NEW BONE
WITH FORTEO